Preparation of one kind of rosiglitazone hydrochloride sustained-release pellets formulations pioglitazone

Pyrazol one kind of acid group of cells with a method and preparation of rosiglitazone sustained release pellet preparation of the pyridine hydrochloride pioglitazone, solubilizing agents and binder are mixed uniformly by the pareil agent prepared as hydrochloride pioglitazone-containing pellet core, Hydrochloride pioglitazone-containing pellets the core is preheated, the sustained release layer coating solution is sprayed onto pyrazole hydrochloride pioglitazone-containing pellets of the core, prepared as pioglitazone hydrochloride sustained-release pellets; and metformin hydrochloride sustained release pellets by mixing the prepared compound metformin hydrochloride pioglitazone sustained release microspheres pellet formulation, so that over the hypoglycemic effect, can reduce the side effects of drugs, to achieve steady hypoglycemic effect in the body, help to improve patient compliance, has a higher bioavailability and stable plasma concentration, can effectively improve the clinical efficacy, better efficacy and dosing regimen for diabetes patients at home and abroad.