Effects of malnutrition on cytochrome P450 1A2 activity in elderly patients

Abstract Little is known of the influence of nutritional status on cytochrome P450 (CYP) 1A2 activity in elderly patients. Thirty elderly institutionalised patients with malnutrition (group A, aged 88 ± 5 years) and 24 without (group B, aged 81 ± 9 years) were included. Malnutrition was defined as weight loss of > 10% over the previous 6 months and/or a body mass index (BMI)