Local fitness landscape of the green fluorescent protein.

Karen S. Sarkisyan,Dmitry A. Bolotin,Margarita V. Meer,Dinara R. Usmanova,Alexander S. Mishin,George V. Sharonov,Dmitry N. Ivankov,Nina G. Bozhanova,Mikhail S. Baranov,Onuralp Soylemez,Natalya S. Bogatyreva,Peter K. Vlasov,Evgeny S. Egorov,Maria D. Logacheva,Alexey S. Kondrashov,Dmitry M. Chudakov,Ekaterina V. Putintseva,Ilgar Z. Mamedov,Dan S. Tawfik,Konstantin A. Lukyanov,Fyodor A. Kondrashov

Local fitness landscape of the green fluorescent protein.

2016

Comprehensive genotype–phenotype mapping of the green fluorescent protein shows that the local fitness peak is narrow, shaped by a high prevalence of epistatic interactions, providing for the loss of fluorescence when the joint effect of mutations exceeds a threshold.

Keywords:

Green fluorescent protein
Genetic Fitness
Fitness landscape
Epistasis
Mutation
Genetics
Biology
Fluorescence
Molecular evolution
Population genetics
Gene

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