Associations Between IL-10 Polymorphisms and Susceptibility to Melanoma, Basal Cell Carcinoma, and Squamous Cell Carcinoma: A Meta-Analysis

Background: A consensus is building that interleukin-10 (IL-10), as a multifunctional anti-inflammatory cytokine, has a critical influence in cancer development. A meta-analysis was carried out regarding the relationships among the -592 A/C, -1082 G/A, and -819 T/C IL-10 polymorphisms and their association with skin squamous cell carcinoma (sSCC), melanoma, and basal cell carcinoma (BCC). Materials and Methods: A meta-analysis was carried out to study the inter-relationships among three IL-10 SNPs and their association with sSCC, melanoma, and BCC. Results: In this analysis, a total of 11 researches, involving 2149 controls and 2128 cases, were included. No association was found between skin cancer risk and any of the alleles of either the -592A/C SNP or the 1082T/C SNP. However, a moderately decreased skin cancer risk was found in the -819 TC versus CC model (odds ratio [OR] = 0.81 and 95% confidence interval [CI] = 0.67–0.99, p = 0.04). From the subgroup analysis, a decreased risk was found between the ...