Bronchial neuroendocrine neoplasms: A Surveillance Epidemiology and End Results (SEER) database review of treatment outcomes.

4098 Background: Bronchial neuroendocrine tumors (NENs) are a biologically heterogeneous group of malignancies with varied approaches to treatment. We queried the SEER database about outcomes of surgery and radiation. Methods: We identified 945331 cases in the SEER database with malignancies of the lung and extracted 187991 bronchial NENs – 130092 cases of small cell carcinoma, 44520 cases of large cell carcinoma, 3349 cases of neuroendocrine carcinoma (grades 3/4 [G3/4]), 9135 cases of typical bronchial carcinoid (grade 1 [G1]), and 895 cases of atypical bronchial carcinoid (grade 2 [G2]) – to examine clinical outcomes by treatment modality, including radiation in 82157 cases and surgery in 21352. Results: Surgical intervention on the primary NEN became less frequent as SEER stage become more extensive; operations were performed in 56.0% of cases of localized disease, 19.9% of regional disease, and 4.5% of distant disease. Proportionately more surgery was performed on lower-grade histologies (e.g. 84% of...