Prospective study on relationship between central obesity and glucose metabolic disorders.

Objective To longitudinally study the relationship between central obesity and glucose metabolic disorders.Methods A seven-year follow-up study was conducted in 321 subjects(body mass index 25 kg/m2) included 125 central obese subjects and 196 normal control subjects who were chosen in 2000.Before and after follow-up, body mass index, waist circumference, blood pressure, lipid profile, fasting blood glucose and 2 hour blood glucose after glucose loading , fasting insulin and insulin resistance index(HOMA-IR) were measured.Results 120 subjects(72 men and 48 women) in central obesity group and 172 subjects(101 men and 71 women) in normal control group were followed up in 2007.The followed up rate of central obese subjects were higher than that of normal control subjects(96.0% vs 87.8%, χ2=4.516,P0.05 ).Seven-year cumulative incidence of impairment glucose tolerance and type 2 diabetes mellitus in male central obese subjects were significantly increased than in male control subjects(both P0.05 ).The total cumulative incidence of glucose metabolic disorders, whether male or female, in central obesity group was higher than that in normal control group(all P0.05).The basal levels of blood pressure, lipid profile, blood glucose and HOMA-IR were significantly increased in the former than in the latter(P0.05～0.01).Compared with the basal levels, the above parameter in central obesity group after seven years follow-up were significantly increased(P0.05～0.01) and no change were found in normal control group.Logistic analysis showed waist circumference(OR=2.53, P0.01) and HOMA-IR(OR=3.12, P0.05)in male and age(OR=2.79, P0.05), body mass index(OR=1.58, P0.01), waist circumference(OR=1.47, P0.05) and HOMA-IR(OR=2.79, P0.05) were major risk factors correlating with glucose metabolic disorders.Conclusion Central obesity and insulin resistance play very important roles in occurrence of glucose metabolic disorders, and this relationship with male is more closely.