Abstract 15204: The Effect of Primary Prevention Statin Therapy on Mortality in Persons With Aortic Atherosclerosis

Introduction: The prevalence of aortic atherosclerosis has increased as a result of greater availability and use of medical imaging. The role of statin therapy in subjects with aortic atherosclerosis, in particular by predicted 10-year risk for atherosclerotic cardiovascular disease (ASCVD), remains unknown. Objective: To determine the effect of primary prevention statin therapy in subjects with aortic atherosclerosis. Methods: We identified 116,720 consecutive subjects with aortic atherosclerosis who did not have known coronary artery disease or stroke between 2009-2013. Propensity score for statin use was calculated using logistic regression and used to match statin users and non-users 1:1. The covariates included in the model were: demographics, cardiovascular risk factors, comorbidities, medications, and resource utilization. Cox proportional hazards models for all-cause mortality were then used to calculate hazard ratios for statin users vs. non-users in the matched cohort. The 10-year estimated ASCV...