A convenient ‘catch and release’ synthesis of fused 2-alkylthio-pyrimidinones mediated by polymer-bound BEMP
2003
Abstract A robust ‘catch and release’ synthesis of fused 2-alkylthio-3-substituted-pyrimidinones mediated by the polymer-bound base P-BEMP is described. This reengineered synthesis combines the efficiency of the classical synthesis (three steps, three diversity points) with the practical benefits of resin-bound reagents. The solution-phase strategy, reagent compatibility, and the results of a representative 48-member combinatorial library are described and presented herein.
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