Risk Factors for Perinatal Transmission of Hepatitis C Virus (HCV) and the Natural History of HCV Infection Acquired in Infancy

P ! .05 HCV RNA negative). In multivariate analysis restricted to HCV RNA‐positive mothers, membrane rupture 6 h (odds ratio [OR], 9.3 [95% CI, 1.5‐179.7]) and internal fetal monitoring (OR, 6.7 [95% CI, 1.1‐35.9]) were associated with transmission of HCV to infants. Conclusion. If duration of membrane rupture and internal fetal monitoring are confirmed to be associated with transmission, interventions may be possible to decrease the risk of transmission.