Expression of hematopoietic progenitor cell associated antigen CD34 in chronic myeloid leukemia.

Abstract The expression of progenitor cell associated antigen CD34 was investigated in cells from 28 patients with chronic myeloid leukemia (CML). The CD34 positivity varied from 0–26% in patients with chronic phases CML ( n = 17); from 6–64% in patients with accelerated phase CML ( n = 4); and from 27–97% in the patients with blastic crisis of CML ( n = 8). The difference in CD34 positivity between chronic (mean 10.1 ± 2.3%), accelerated (37.7 ± 13.3%) and blastic (58.0 ± 7.3%) phases of CML is statistically significant ( p