Reply to Sabbioneda et al.: Role of ubiquitin-binding motif of human DNA polymerase η in translesion synthesis

Sabbioneda et al. (1) conclude “that the UBZ motif of Polη is required for correct localization of Polη when cellular concentrations of PCNA are unperturbed.” However, our observations that the C635A and H650A mutations confer no significant increase in UV sensitivity (,2) imply that inactivation of Ub-binding ability of the UBZ domain via these …