The effect of MP29-02* is mediated via bitter taste receptors (TAS2R)

Background Dymista (MP29-02*) is a novel intranasal formulation of azelastine hydrochloride (AZE) and fluticasone propionate (FP) in an advanced delivery system with a welldocumented effect on allergic rhinitis. Its somewhat bitter taste is probably derived from AZE, a potent histamineH1-receptor antagonist. The taste is sometimes looked upon as a disadvantage. However, it might be that AZE induces some of its beneficial effect through activation of bitter taste receptors. Recent evidence indicates that bitter taste receptors are present in human upper airway mucosa in regions associated with high airflow and particulate deposition. Consequently the MP29-02* effects might be due not only to its anti-histaminic, mast-cell stabilizing, anti-leukotriene, and anti-inflammatory properties but also as due to activation of bitter taste receptors.