Экзогенный фосфокреатин как кардиопротектор в хирургии и интенсивной кардиологии. Аналитический обзор

Creatine phosphate (CrP) plays a fundamental physiological role by providing chemical energy for muscle cell viability and activity. Numerous pathological conditions, such as acute ischaemia-repertusion, and cardiac deseases, are related to its deficiency. For these reasons, it has been used as a car-dio-protective agent in heart surgery and intensive cardiology. Many experimental and clinical trials with exogenous CrP have provided further interesting in formation on the pharmacological role of this molecule. This article gives a brief overview of the main characteristics of exogenous Cr P. Besides CrP s well known cell energy and function restoring properties, new evidence is emerging regarding its antioxidant and antiapoptotic properties. Use of CrP is well established clinically as an intraoperative and perioperative adjuvant in cardiosurgical, vascular and oncological procedures, and as an additional agent in cardiology therapy for acute myocardial infarction.