Effect on the lipid parameters of an intervention to reduce weight in overweight and obese patients

Abstract Objective To assess the effect on lipid parameters most associated with excess weight (triglycerides [TG], cholesterol, and high density lipoprotein [HDL-C]) of an intervention to reduce weight in overweight and obese patients. Methods A randomised, controlled, double blind clinical trial, with three groups, and a follow-up of 12 months. Patients included in the study were randomised into three intervention groups: Obesity motivational intervention group with previously trained nurse (G1), lower intensity consultation, non-motivational group, with digital platform support (G2), and a third group that received a recommendation to lose weight and usual follow-up (G3). The anthropometric variables measured were height, weight, and abdominal/waist circumference, and laboratory results, total cholesterol, TG and HDL cholesterol). Results The study includes 176 patients, of whom 60 were randomised to G1, 61 to G2, and 59 to G3. All groups significantly decreased body weight at the end of the study, with a decrease in G1 (−5.6 kg), followed by G2 (−4.3 kg), and G3 (−1.7 kg), with an overall mean loss of −3.9 kg. There was also a significant decrease ( p Conclusions Weight reduction is accompanied by favourable changes in the lipid parameters related to overweight and obesity, being more intense the greater the weight loss.