Characterization of Nanoparticle Dispersions by Size and Scattering Intensity Simultaneously

A novel multi-parameter characterization system for nanoparticles is described. This system builds on the Nanoparticle Tracking and Analysis (NTA) technique for the simultaneous visualization and individual sizing of nanoparticles based on their Brownian motion. NTA employs a novel particle illumination method, allowing direct observation of particles in suspension. The technique described is extended to allow not just the characterization of size, but also light scattering intensity on an individual particle-by-particle basis. This multi-parameter measurement capability allows sub-populations of nanoparticles of varying characteristics to be resolved in a complex mixture. Changes in one or more of such properties can be followed in real time and in situ.