C URRENT OPINION Genetics of multiple sclerosis: swimming in an ocean of data

Purpose of reviewMajor advances in the genetics of multiple sclerosis (MS) have been reported in 2011. These includestudies in gene mapping, functional characterization of previously associated genes, and the relationshipbetween genes and the environment. While particularly true for gene discovery, each of these effortsrequires substantial statistics and computational resources for adequate analysis. This review describes themajor advances in the genetics of MS with a slight emphasis on data handling and analysis.Recent findingsArticles discussed include a new genome-wide association study (GWAS) with almost 10 000 cases(a collaboration between the Wellcome Trust and the international MS Genetics Consortium) that identifiednew susceptibility loci, taking the total number of risk alleles to more than 50. An article describing the useof next-generation sequencing to identify a rare mutation in CYP27B1 in a MS family is also discussed.Moreover, a summary of recent reports describing functional studies of MS-associated genes as well as thelatest research on the interactions between genes and the environment is provided.SummaryThis review provides a concise summary of the most relevant studies in the genetics of MS in the past year.We raise awareness about analytical resources to successfully analyze the massive datasets characteristicof today’s genetic studies.Keywordsbioinformatics, genetics, multiple sclerosis