[Effect of anhydrous glycerol injection into the mental foramen of rabbit on inferior nerve:An experimental study]

: In this experiment anhydrous glycerol was injected into the mental foramen of rabbits to determine neurolytic effects on the peripheral trigeminal nerve by electrohysiologic and morphologic methods.The rabbits underwent unilateral injection of anhydrous glycerol and the control side was injected with normal saline.The results show that partial fibers are effected (myelinated and unmyelinated fibers at random).Glycerol injection increased the average latencies and reduced the average amplitudes of compound action potentials.Morphologic examination disclosed myelin swelling,disintergrationan d axonal shrinking,axonolysis.One week after the injection,eletrophysiologic and morphologic changes were most severe and signs of regeneration were noted in the fifth week,By 16 weeks after injection,the nerve fibers appeared almost normal.