Efficacy of a Dermoxen® lenitiva for pruritus genitalis in a randomized, double blind trial.

BACKGROUND: Pruritus can be defined as an unpleasant cutaneous sensation associated with the immediate desire to scratch. In particular external intimate zone could be hit by pruritus genitalis because of several reasons (bacterial infection, fungal infection, stress, bad intimate behavior, synthetic intimate clothes). AIM: The aim of the study was to compare the efficacy of Dermoxen ® Lenitiva cream versus a methylprednisolone aceponate 0.1% based cream in treating pruritus of the external genitalia . PATIENTS AND METHODS: Independent, ran - domized, double-blind, controlled trial in two Uni - versity affiliated Italian Hospitals. 80 women, af - fected by aspecific pruritus genitalis with nega - tive vaginal swab for bacterial or fungal infections or other pathogenic causes of itching, were se - lected and blindly treated by Dermoxen ® Lenitiva cream or methylprednisolone aceponate 0.1% based cream. The main outcome measures were: the reduction of sensation of pruritus, evaluated by a visual analog scale (VAS) pain score, and im - provement of intimate wellness sensation, and comfort during sexual intercourse, frequency and severity of adverse reactions. RESULTS : Significant reduction of itching sen - sation was verified for each treatment. CONCLUSIONS: Based on our results, Der - moXen ® Lenitiva vaginal cream showed efficacy so as methylprednisolone aceponate 0.1% based cream for itching treatment on external fe - male genitalia and improved intimate comfort and comfort in sexual intercourse.