Effect of generalized unspecifical immunoreaction on thefunction of rat testis —— The morphological changes of the testis

In this experiment, we used the male SD rats as the object to observe what would happen about the spermatogenesis of the testes under the condition of generalized, unspecifical immunoreaction, which was induced by intravascular injection of Indian Ink. In the experiment group, after the rats had received injection of carbon particles, once a day, for ten days, the counts of blood white-cells (4.09×10 4±1.22×10 4/mm 3) of the rats were obviously higher than that in the control (1.58×10 4±0.41×10 4/mm 3, P0.001 ). The testes were atrophia and (or) hyperemia to different extent, and the testis weight (0.651±0.102g/100g body weight) decreased obviously compared with that in the control (0.795±0.162g/100g body weight, P0.05 ). Observed under light microscope, the testes of experiment group showed that in some seminiferous tubules the spermatogenic cells were selectively falling from seminiferous epithelium into the lumine of the tubule and, at some region of tubules, the cells appeared to have reversed arranges. Meanwhile, in some other tubules, the spermatogenic cells vanished completely from the seminiferous epi thelium or all the tubular cells showed pyknosis, and in the interstitial tissue the number of cells increased obviously. We believe that the generalized unspecifical immunoreaction induced by intravascular carbon particle injection can make a harmful effect on the testis, this effect is perhaps carried out by different ways.