Change of neuronal avtivity of GABAergic interneurons in mPFC of hepatocellular carcinoma model tats

Objective:To study the neuronal avtivity of GABAergic interneurons in mPFC in hepatocellular carcinoma rat.Methods: The change of spontaneous firing of GABAergic interneurons in mPFC in hepatocellular carcinoma rat in vivo was observed.Results: The firing rate of GABAergic interneurons in mPFC increased significantly from(5.56±0.66) Hz to(9.24±0.53) Hz(P0.01),and the firing pattern of these neurons changed significantly towards a more bursting firing(P0.01).Conclusion: Change of neuronal avtivity of the GABAergic interneurons in mPFC of hepatocellular carcinoma rat was fcund.