The role of γ/δ T cells in immunity to infection and regulation of inflammation

The role of γ/δ T cells in immunity to bacterial infection and control of inflammation is discussed. Special emphasis is placed on the use of murine models in which various aspects of immune function can be monitored in the absence of γ/δ T cells. Issues discussed include the response to and control of cytokine production by γ/δ T cells. Especially relevant is the apparent paradox that γ/δ T cells play both pro-inflammatory and antiinflammatory roles in response to infection.