Thirteen years of culture-positive M. bovis-BCG infection in an IL-12Rβ1 deficient patient: Treatment and outcome
2006
Summary Patients with mutations in the IFNγ/IL-12 pathway show an exquisite susceptibility to mycobacterial diseases. An IL-12Rβ1 deficient patient with impaired intestinal absorption suffered from a 13 year culture-positive Mycobacterium bovis -BCG infection with acquired multidrug resistance. A combined parenteral and enteral anti-mycobacterial treatment, including recombinant IFNγ, helped to clear his infection.
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