Association between OPG, RANK and RANKL gene polymorphisms and susceptibility to acute coronary syndrome in Korean population

B ligand (RANKL), its receptor RANK and osteo-protegerin (OPG) are members of tumour necrosis fac-tor (TNF) superfamily and they form a key cytokine triadinvolved in bone metabolism, specifically osteoclastogen-esis (Khosla 2001; Boyce and Xing 2008). Recent stud-ies have demonstrated that OPG/RANK/RANKL system isinvolved in plaque instability and rupture by inducing plaquecalcification (Panizo