Development of in Vitro Microfluidic Circulatory System

This paper reports the very first microfluidic circulatory platform mimicking physiological micro-environments in vitro to investigate cell interactions between different organs, and between organs and blood vessels. The platform consisting of a heart-mimicking pump, a device with blood-air barrier and a blood vessel-like micro-channel is demonstrated in this paper. Moreover, the platform can also include other well-developed organ-on-a-chip devices for advanced biomedical researches. In this paper, we exploit the developed platform to study endothelium responses and its interaction with epithelial cells at a blood-air barrier under biomimetic pulsatile flow perfusion.