EFFECT OF POLACRILIN PATASSIUM ON THE PHYSICOCHEMICAL PROPERTIES OF CARVEDILOL IMMEDIATE RELEASE TABLET

The consistency of superdisintegrant performance is important to increase the rate of dissolution and hence its bioavailability. There are various factors (hardness, concentration of binders, disintegrants etc) affecting the disintegration time and rate of dissolution of the drug. The aim of the present investigation was to formulate and evaluate immediate release tablets of a poorly soluble drug, carvedilol, a beta-adrenergic blocking agents, indicated for the treatment of hypertension, angina pectoris, and heart failure and to investigate the joint influence of two formulation variables i.e. concentration of the superdisintegrants, Polacrilline K (Kyron T 314) and hardness of the tablets on the disintegration time (DT) of the tablet. The tablets were formulated by using wet granulation technique, evaluated their physicochemical characteristics and, the effects of hardness and disintegrants on DT were accessed. The concentration of Polacrilline K was inversely related to disintegration time. The reverse relation of hardness of tablets was found with DT. It is thus concluded that the stable and robust immediate release tablets of carvedilol can be formulated by using optimum concentration of Polacrilline K at desired hardness.