INHIBITION OF TUMOR-CELL INVASION AND GELATINASE PRODUCTION IN METASTATIC HUMAN GASTRIC-CARCINOMA CELLS BY RETINOIC ACID AND BESTATIN

: We have selected a human variant gastric carcinoma cell line (MKN45H) with increased metastatic potential in nude mice to study the properties of metastatic cells, and investigated the effects of retinoic acid (RA), interferon-gamma and bestatin on invasion and gelatinase production by MKN45H cells. The MKN45H cells showed increased invasive phenotypes and greater secretion of gelatinases as compared to the parental cells. Treatment with RA and bestatin significantly decreased invasion through Matrigel and production of gelatinases by MKN45H cells. These results suggest that RA and bestatin may be useful for the inhibition of invasive potential of gastric carcinoma.