ARV regimen choice and co-morbidities

The main HIV co-morbidities include coronary heart disease (CHD), metabolic syndrome and lipodystrophy, renal impairment, fragility fractures, neurocognitive disease, and the emerging complications of insulin resistance and fragility fractures. The evidence base for toxicities seen with ART is gained mainly from comparative efficacy studies of ART regimens, where toxicity is not the primary endpoint, or cohort studies, with their inherent limitations.