Активность фактора Виллебранда у крыс после кратковременной ишемии головного мозга

The von Willebrand factor (vWF) is a recognized marker of endothelial dysfunction associated with an imbalance in endothelial production of substances with procoagulant activity. vWF activity and hematocrit index in Wistar rats after 12 min occlusion of both carotid arteries with simultaneous controlled hypotension to 45±3 mm Hg, was investigated. Post-ischemic changes were evaluated in 5 groups of rats: 1 hour and 3, 7, 14 and 21 days after ischemia. An increase in the activity of vWF was manifested as early as 1 hour after ischemia. By the 3rd day of the post-ischemic time, the concentration of vWF in the blood plasma decreased as a result of hemodilution, as evidenced by hematocrit decrease. After 7 days there was a sharp increase in the activity of the marker. In the future, the activity of vWF decreased and by 21 days after ischemia, the values of the vWF activity reached values in control rats. It was established that cerebral ischemia led to the development of vascular endothelial dysfunction associated with an imbalance of endothelial production of substances with procoagulant activity, which persists for 14 days after ischemia.