immunogenic compositions comprising polypeptides of mycobacterium tuberculosis and fusions thereof

A composition comprising an immunostimulant and a combination of three or more antigens of Mycobacterium tuberculosis, wherein the combination of the three or more antigens comprising SEQ ID NO: 26 (Rv2608), SEQ ID NO: 51 (Rv3620), and SEQ ID NO: 16 (Rv1813) or comprises an antigen having at least 90% identity with SEQ ID NO: 26, an antigen having at least 90% identity with SEQ ID NO: 51, and an antigen having at least 90% identity with SEQ ID NO: 16.