Prevention of Neural Tube Defects and proper folate periconceptional supplementation.

: Patients receive medications appropriate to their clinical needs, in doses that meet their own individual requirements, for an adequate period of time, and at the lowest cost to them and their community." (WHO, 1985).The WHO statement on the rationale use of medicines, and the reasons why medicines are often used irrationally should be carefully considered even in the present days, as physician must face lack of knowledge, limited economic resources, and a plethora of therapeutic suggestions.