Inhibition of matrix metalloproteinases by P1 substituted N-carboxyalkyl dipeptides
1996
Abstract Aroyl and arylacyl aminoalkyl substitutents at the P 1 position of N -carboxyalkyl dipeptides were found to enhance potency and selectivity for stromelysin-1 (MMP-3). In particular, the phthalimidobutyl and phenylpropanoylaminopropyl groups offered inhibitors of MMP-3 with K i 's of ∼ 10nM.
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