Does hyperketonemia affect protein or glucose kinetics in postabsorptive or traumatized man

Abstract Leucine and glucose turnover were measured using simultaneous infusions of [ 13 C]leucine and [ 2 H]glucose before and during an infusion of Na dl -hydroxybutyrate (Na dl -HB) in overnight-fasted patients the day before and 3 days after total hip replacement. The ketone body infusion before surgery resulted in a significant increase in plasma leucine concentration and leucine turnover, while glucose concentration and turnover decreased. Surgery increased leucine turnover. Ketone body infusion after surgery caused a further increased leucine turnover while turnover fell as before surgery. We suggest that exogenous ketone bodies decrease hepatic glucose production and probably stimulate a rise in protein synthesis above breakdown leading to a decreased nitrogen excretion as observed by other investigators. Despite the metabolic adaptation to trauma, this response was not affected by surgery.