XPO1 inhibitors represent a novel therapeutic option in Adult T-cell Leukemia, triggering p53-mediated caspase-dependent apoptosis.

Vallve, Maria Lourdes Farre. Fundacao Oswaldo Cruz. Instituto Goncalo Moniz. Salvador, BA, Brasil. 1KU Leuven Department of Microbiology, Immunology and Transplantation, Laboratory of Virology and Chemotherapy, Rega Institute, B-3000 Leuven, Belgium. 2KU Leuven Department of Microbiology, Immunology and Transplantation, Laboratory of Clinical and Epidemiological Virology, Rega Institute, B-3000 Leuven, Belgium. 3Karyopharm Therapeutics, Newton, MA, USA. 4Instituto de Pesquisa Goncalo Moniz, Oswaldo Cruz Foundation (FIOCRUZ), Salvador, Bahia, Brazil. 5HUPES, Federal University of Bahia (UFBA), Salvador-Bahia, Brazil. 6Department of Pathology and Tumor Biology, Kyoto University, Kyoto, Japan