Antithrombotic drugs apixaban preparation

The present invention relates to the field of preparing pharmaceuticals, specifically it relates to a method for preparing the apixaban, which is p-chloroaniline as a starting material chloride and amidation - ring closure to give compound III1- (4- chlorophenyl) -2- piperidone. Hydrazine hydrazone bonded - (Klingemann Japp-Klingmann Yap), to give compound VI [(4- methoxyphenyl) After starting material methoxyaniline with 2-chloro ethyl acetoacetate continued diazotization yl] ethyl chloride. Compound III with a starting material 5,6-dihydro-3- (4-morpholinyl) -2 (1h) - pyridone substitution reaction occurs in the catalyst to give compound 5,6-dihydro-2-3- (4-morpholinyl yl) -1- [4- (2-oxo-1-piperidinyl) phenyl] -2 (1H) - pyridinone; compound VI and VIII occurs compound [3 + 2] cyclization - elimination to give compound IX , compound IX is reacted with ammonia to give apixaban, the crude product was washed to obtain high purity alcohol apixaban, total yield 40% -50%. Material of the present invention is simple, low in cost, mild reaction conditions, by-products and less easily give high-purity product suitable for industrial production.