Altered efficacy of AT1R-targeted treatment after spontaneous cancer cell-AT1R upregulation
2011
Background
Targeting of the renin angiotensin system (RAS) reduces tumour growth in experimental models of cancer. We aimed to establish if combined targeting of the 'classical' and 'alternative' arms of the RAS could result in synergistic inhibition of colorectal cancer (CRC) liver metastases.
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