Effect of nitrate supplementation on hepatic blood flow and glucose homeostasis: a double-blind, placebo-controlled, randomized control trial

This is the first study investigating the effect dietary nitrate supplementation on hepatic blood flow and on incretin and C-peptide concentrations in young and older adults. Despite a physiologically relevant elevation in plasma nitrite concentration following an acute dose of 11.9 mmol nitrate, there was no effect on hepatic blood flow, plasma glucose, C-peptide, or incretin concentration. Acute supplementation of nitrate does not appear to alter hepatic diffusion or modulate postprandial glucose homeostasis.