Functional and Nonclinical Similarity of ABP 980, a Biosimilar of Trastuzumab

Shea Jassem,Wei Wang,Heather Sweet,Raffi Manoukian,Vincent Chow,Palanisamy Kanakaraj,Katariina M. Hutterer,Scott Kuhns,Ian Foltz,Qing Chen,John Ferbas,Helen J. McBride

Functional and Nonclinical Similarity of ABP 980, a Biosimilar of Trastuzumab

2019

Shea Jassem
Wei Wang
Heather Sweet
Raffi Manoukian
Vincent Chow
Palanisamy Kanakaraj
Katariina M. Hutterer
Scott Kuhns
Ian Foltz
Qing Chen
John Ferbas
Helen J. McBride

Purpose The in vitro and in vivo pharmacologic assessment of ABP 980 similarity to its reference product is intended to compare the activity of ABP 980 and trastuzumab and support the overall conclusion of similarity based on a comprehensive analytical and functional evaluation.

Keywords:

Chemistry
In vivo
Breast cancer
Pharmacology
Biosimilar
Trastuzumab
Biochemistry
In vitro
Internalization
Monocyte
Docetaxel
In vitro toxicology
Computational biology

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