Synthesis and studies of novel homoveratryl based thiohydantoins as antibacterial as well as anti-HIV agents
2006
N,N'-bis(3,4-dimethoxyphenylethyl)-5-(arylidene)-2-thiohydantoins 3a-j have been prepared by condensation of 1,3-diaryl-2-thiohydantoin 2 with various aromatic aldehydes. The compound 2 has been prepared by the reaction of N,N'-bis(3,4-dimethoxyphenylethyl)thiourea 1 with chloroaceticacid. The compounds have been tested for their antibacterial and anti-HIV activities against different microorganisms. The structures of novel synthesized compounds have been established on the basis of elemental analyses, 'H NMR, IR and mass spectral data.
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