THE VALUE OF MICROBIOLOGICAL MONITORING AND DETERMINING THE MOLECULAR GENETIC CHARACTERISTICS OF HOSPITAL MICROFLORA OF PURULENT OSTEOLOGY DEPARTMENT

434 microbial strains found in Purulent Osteology Department patients were analyzed. 203 infectious agents were found in patients with purulence after major joint prosthetics, 148 - in patients with chronic osteomyelitis, 83 - in diabetic foot patients. Grampositive microorganisms accounted for 302 strains, gram-negative ones - for 132 strains. Irrespective of nosology, main infectious agents were represented by various staphylococci, a third of which expressed mec A gene displaying a phenotype of methicillin-resistant strains. Ps. Aeruginosa was second in detection rate, among which 9 strains out of 51 had a gene encoding VIM-type Metallo-beta-lactamase production. The third place in detection rate belonged to A. baumanii. 15 strains producing OХА-40-like carbapenemases were found among 29 acinetobacter isolates. 14 out of 19 K. pneumoniae strains produced extended spectrum beta-lactamases. Therefore, similar patterns in infectious agent structure were found in Purulent Osteology Department patients with various infectious processes: staphylococci predominance and circulation of a great number of antibiotic multiresistant microorganisms. A thorough microbiological monitoring enables determining of phenotype and genotype of antibiotic resistance and prescribing a balanced antimicrobic therapy.