Magnesium Sulfate Versus Diazepam Infusion in Eclampsia

Abstract:   The anticonvulsant has key role in management of eclampsia but the choice is still controversial. Objectives:   To compare the efficacy of magnesium sulfate and diazepam infusion as good anticonvulsant. Study Design   The study was conducted at Obst/Gynae Unit -II, Punjab Medical College, DHQ Civil Hospital, Faisalabad from 1 st May, 2007 To 30 th December,2007. Material and Methods:   There were total 3506 deliveries in 8 months among 45 cases of antenatal eclampsia were selected. The cases of postpartum eclampsia, gestational age less than 28 weeks, and dead fetuses were excluded. 25 patients were allocated Mgso 4 and 20 patients treated with Diazepam infusion regardless of prior therapy. The dosage of both was monitored clinically. Morbidity was defined in terms of maternal and fetal measures. Results:   MGSO4 was the better anticonvulsant than diazepam infusion in terms of total morbidity, the value (P < 0.05), recurrence of fits (16% versus 30%), maternal deaths (Null versus 5%), respiratory depression (Null versus 10%). Mgso4 was associated with better outcomes in terms of total fetal morbidity (28% versus 90%) and perinatal deaths (4% versus 15%) than diazepam the value (P < 0.05). Fewer babies in Mgso4 group had low apgore score at 1 minute (12% versus 25%), at 5 minute (Null l% versus 10%), required less intubations (8% versus 25%) and required less admission in special care unit (4% VS 15%) than diazepam group. Key Words:   Magnesium sulfate (Mgso4), Diazepam infusion, Eclampsia.