INTRAVENOUS PARACETAMOL INFUSION CAN PROLONG DURATION OF SPINAL ANESTHESIA IN PATIENTS UNDERGOING MAJOR GYNECOLOGICAL SURGERIES

Intravenous infusion of paracetamol is recently being used widely for pain control during intra -operative as well as post operative period. Paracetamol is primarily thought to be cyclooxyge nase inhibitor acting through the central nervous system.This study was designed to evaluate the effect of single pre -operative intravenous infusion of paracetamol on spinal blockade in patients undergoing major gynecological surgery. One hundred ASA I an d II patient aged 30 -60 years undergoing elective major Gynecological surgery under spinal anesthesia were included in this randomized double blind study. The patients were randomly allocated to receive either 1 gm/100 ml paracetamol Group A (n=50) or 100 ml normal