Feasibility of 3-D Bioprinting With a Modified Desktop 3D Desktop Printer.
2016
Abstract Numerous studies have shown the capabilities of 3D printing for use in the medical industry. At the time of this publication, basic home desktop 3-D printer kits can cost as little as $300, while medical-specific 3D bioprinters can cost upwards of $300,000. The purpose of this study was to show how a commercially available desktop 3D printer could be modified to bioprint an engineered poly-L-lactic acid (PLLA) scaffold containing viable chondrocytes in a bioink. Our bioprinter was used to create a living 3D functional tissue-engineered cartilage scaffold. In this article we detail the design, production and calibration of this bioprinter. Additionally the bioprinted cells were tested for viability, proliferation, biochemistry, and gene expression; these tests showed the cells survived the printing process, were able to continue dividing, and produce the extracellular matrix expected of chondrocytes.
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