Оценка генотоксичности тетрахлорметана и защитного действия силибинина и хаурантина с помощью метода ДНК-комет в печени крыс

The authors have studied the carbon tetrachloride-induced DNA degradation in liver of rats with DNA-comet assay (microelectrophoresis of DNA in a single cell). As reported, the hepatotoxicity estimated by the comet profile arose from hepatocyte genome damage. Medication Silibinin derived from Silibium marianum (L.) Gaertn. and extraction of tunic of Halocynthia aurantium Haurantin exhibited genoprotective action. The paper considers major mechanisms of destructive action of carbon tetrachloride.