High-dose aprotinin does not affect troponin I, N-Terminal pro-B-type natriuretic peptid and renal function in children submitted to surgical correction with extracorporeal circulation Aprotinina não influencia troponina I, NTproBNP e função renal em crianças operadas com circulação extracorpórea

AbstractObjective: To evaluate if the use of hemostatic high-doseaprotinin seems influence to myocardial, renal andmetabolic functions in children submitted to surgicalcorrection with extracorporeal circulation (ECC). Materialand Methods A prospective randomized study was conductedon children aged 30 days to 4 years submitted to correctionof acyanogenic congenital heart disease with ECC anddivided into two groups: Control (n=9) and Aprotinin (n=10).In the Aprotinin Group the drug was administered beforeand during ECC and the myocardial and multiorgandysfunctions were analyzed on the basis of clinical andbiochemical markers. Differences were considered to besignificant when P <0.05. Results: The groups were similar regarding demographicand intraoperative variables, except for a greaterhemodilution in the Aprotinin Group. The drug had nobenefit regarding time of mechanical pulmonary ventilation,permanence in the pediatric postoperative intensive careunit (ICU) and length of hospitalization, or regarding theuse of inotropic drugs and renal function. The partialarterial oxygen pressure/inspired oxygen fraction ratio(PaO