Синтез аналогов фитановой кислоты и изучение их влияния на холестеринэстеразу печени человека in vitro

Ten acyclic isoprenoid fatty acids were synthesized and tested in vitro as plausible regulators of the cholesterol/cholesteryl alcanoate ratio in the blood serum lipoproteins. Racemic C 20 -analogs of (3 R / S ,7 R ,11 R )-3,7,11,15-tetramethylhexadecanoic (phytanic) acid proved to potential vitro activators of the human liver cholesterol esterase (HLCE). Achiral ( E , E )-5,9,13-trimethyltetradeca-4,8,12-trienoic (farnesylacetic) acid, a non-toxic anti-ulcer substance, also significantly accelerates the hydrolysis of cholesteryl palmitate catalyzed by HLCE.