Xanthoma of the Sphenoid Sinus: A Rare Presentation

Objectives:1) Present what is to the best of our knowledge the first reported case of a patient with a sphenoid sinus xanthoma. 2) Discuss the details of the clinical presentation, histopathological and radiological findings, and management of this patient.Methods:Medical charts and the scientific literature were reviewed.Results:A 36-year-old female patient with family history of hyperlipidemia presented with a 1-year history of sporadic epistaxis and an episode of severe headache 2 months prior to evaluation. The rest of her medical history and physical examination were unremarkable. Computed tomography (CT) scan and magnetic resonance images revealed a soft tissue lesion occupying and infiltrating the posterolateral aspect of an expanded sphenoid sinus on the left side. Patient underwent endoscopic sinus surgery in December 2011 with intraoperative findings of a yellow-tan, friable soft tissue filling the left sphenoid sinus. Biopsy was taken for which histologic and immunohistochemical analysis reveal...