Percutaneous Coronary intervention in Small Coronary Arteries

G. Dangas, A. J. Lansky, M. Negoita, I. Hjazi, D. Ashby, C. Costantini. M. Guiry, Ft. Brandwein, M. Losquadro. J. Forman. J. W. Moses. G. W. Stone, M. B. Leon, R. Mehran, Cardiovascular Research Foundation, Lenox Hi// Heat? & Vascular Institute. New York, New York. Background. Contrast induced nephropathy (CIN) after PCI is associated with increased mortality. However, the role of gender in the development and prognosis of CIN is unknown. Methods and results. Of 6,626 pts who underwent PCI at a single center, 1431 (16.5%) developed CIN, defined as >25% increase in serum crsatinine value compared to pre- PCI. CIN occurred in 23.6% of female vs. 17.4% of male patients (pcO.OWl). By multivariite analysis female gender (OR= 1.4, p~O.0001). chronic renal failure (CRF, defined as pre- PCI serum creatinine value >lSmg/dl) (OR= 1.6, pcO.0001). diabetes (OR=1.5. pcO.OOOl), age (OR=l.Ol, pcO.0001). and hypertension (OR= 1.2, p=O.O035) were inde- pendent predictors of CIN. Kaplan-Meier estimates of l-year survival after CIN according to gender and baseline (pm-PCI) CRF status are indicated in the figure.