AB0755 REGIONAL AND TEMPORAL VARIATION IN THE BASELINE PROFILE OF PSORIATIC ARTHRITIS PATIENTS INITIATING ADALIMUMAB FOLLOWING FAILURE OF NON-BIOLOGIC TREATMENT IN CANADIAN ROUTINE CARE

Background Treatment selection in routine clinical care is driven by treatment guidelines, physician judgment, patient preferences, and regional reimbursement policies, which may vary over time and among geographic regions. Objectives The objective of this analysis is to investigate the regional and temporal variability of the profile of anti-TNF naive psoriatic arthritis (PsA) patients at initiation of adalimumab (ADA) treatment following failure of initial non-biologic treatment. Methods COMPLETE-PsA is an ongoing Canadian observational study of anti-TNFα naive adults with active PsA who require change in their current treatment as per the judgement of their treating physician. Patients are followed for up to 2 years. Regional variation was assessed for the following regions: British Columbia/Manitoba (BC/MB), Newfoundland/Nova Scotia (NL/NS), ontario (ON), and Quebec (QC). Temporal variation was assessed for the following periods: 2012-2014 and 2015-2017. Multivariate linear regression was used to evaluate the independent impact of region and time period on disease activity (DAS28) and patient function (HAQ). Results A total of 278 patients were included, of whom 68 (24.5%) were from BC/MB, 25 (9%) from NL/NS, 104 (37.4%) from on, and 81 (29.1%) from QC. One hundred fifty-three patients (55%) were enrolled in 2012-2014 and 125 (45%) in 2015-2017. Using univariate analysis, significant regional variation at aDA initiation was observed for the following disease parameters: BSA Conclusion The results of this analysis demonstrate that there is significant regional and temporal variation in the profile of PsA patients initiated on aDA treatment in Canadian routine care. The impact of this profile variation on treatment outcomes requires further investigation. Acknowledgement The authors wish to acknowledge JSS Medical Research, Montreal (QC) Canada for statistical analysis, medical writing and editorial assistance during the preparation of this abstract, and Nathalie Ross, PhD, for editorial assistance. AbbVie provided funding to JSS Medical Research and Nathalie Ross for this work. Disclosure of interests Majed Khraishi Consultant for: abbVie, Speakers bureau: abbVie, Louis Bessette Grant/research support from: amgen, BMS, Janssen, Roche, UCB, abbVie, Pfizer, Merck, Celgene, Sanofi, Lilly, Novartis, Consultant for: amgen, BMS, Janssen, Roche, UCB, abbVie, Pfizer, Merck, Celgene, Sanofi, Lilly, Novartis, Speakers bureau: amgen, BMS, Janssen, Roche, UCB, abbVie, Pfizer, Merck, Celgene, Sanofi, Lilly, Novartis, Samuel Silverberg Consultant for: abbVie, Janssen, Boulos Haraoui Consultant for: abbVie, amgen, Eli Lilly, Merck, Pfizer, Sandoz, UCB, BMS, Janssen, Pfizer, Speakers bureau: amgen, Pfizer, and UCB, andrew Chow Consultant for: abbVie, amgen, BMS, Celgene, Janssen, Lilly, Merck, Novartis, Pfizer, Roche, Speakers bureau: abbVie, BMS, Janssen, Pfizer, Takeda, Yatish Setty Consultant for: abbVie, Valencia P. Remple Shareholder of: abbVie, Employee of: abbVie