Abbreviated Aerosol Therapy for Improved Efficiency

ABSTRACT Background: The Circulaire nebulizer system (WestMed, Tucson, AZ) has been shown to minimize the potential for side effects from adrenergic bronchodilator aerosols by minimizing extrapulmonary deposition. This study evaluates the utility, safety, and efficacy of a shortened treatment protocol utilizing a timed treatment with concentrated drug in this device. Methods: Prospective, randomized, controlled comparison was conducted of a 2-minute treatment of concentrated (5 mg/mL) albuterol in the Circulaire nebulizer versus a conventional unit dose treatment as assessed by pulmonary function testing. Results: Both treatments were equally efficacious and safe. The abbreviated treatment consumed about 8 to 10 minutes less and was preferred by patients. Conclusions: Abbreviated treatments provide equal bronchodilation with improved efficiency and potential cost savings.