HEPATOPROTECTIVITY ACTIVITY OF MEDICINAL PLANT EXTRACTS ON ALBINO RATS

Plants used in traditional medicine have stood up to the test of time and contributed many novel compounds for preventive and curative medicine to modern science. India is sitting on a gold mine of well recorded and traditionally well practiced knowledge of herbal medicine. The present experiment was conducted for 15 days to evaluate the hepatoprotective activity of plant Elytraria acaulis in CCl4 (1ml/kg) treated rats. The extracts were prepared by the Elytraria acaulis whole plant extracts in methanol and aqueous solvents through maceration technique. The 6 groups were maintained as control, CCl4 induced, CCl4+ Liver tonic, CCl4+Elytraria acaulis extracts (propanol 200mg/kg and aqueous 200mg/kg). On the 16 th day blood was collected for the study of serum enzymes like SGOT (Serum Glutamate Oxaloacetic Transaminase), SGPT (Serum Glutamate Phosphate Transaminase) and bilirubin and then the separated liver is processed for the histological studies. The decreased levels of SGOT, SGPT and total bilirubin in the treated rats were an indication of the hepatoprotective activity of extracts of Elytraria acaulis. The histological changes are also evidence for hepatoprotective activity of extracts. Pharmaceutical Sciences